The new 200-square-metre banner is situated in Deansgate and BlowUp claims the site will provide 900,000 impacts per fortnight.
Bulmers' 'In The Beginning' campaign, created by Adam & Eve/DDB and booked by Starcom MediaVest, aims to emphasise the brand's heritage as a pioneering Great British cider since 1887.
The giant poster activity is supported by a broader outdoor, digital and press push later this month.
Aimee McKay, sales director at BlowUp Media UK, said: "This site marks our continued drive to secure big, bold, premium advertising sites in the best city centre locations. Deansgate offers unrivalled standout in the heart of Manchester and captures a broad section of the city by day and by night."Follow @nickbatten2