Compton, who leaves to become the chief executive of Pilot Flying J Oil Corporation, was appointed to the newly-created position of PepsiCo's first president in March, charged with the responsibility for global marketing and driving "breakthrough innovation" throughout its operations.
He is replaced by Zein Abdalla, currently the chief executive of PepsiCo Europe. Abdalla will in turn be replaced by PepsiCo's global nutrition group president Enderson Guimaraes, whose replacement has not yet been announced. All the changes are effective immediately.
Abdalla will now oversee PepsiCo's global category groups, consisting of global beverages, global snacks and global nutrition, its global operations, and its global marketing services and corporate strategy.
Abdalla's team will be charged with driving innovation and brand-building, while "significantly" reducing the overall cost structure of the company.
Indra Nooyi, PepsiCo chairman and chief executive, said: "We are sad to see John leave PepsiCo. John joined PepsiCo as a 21-year-old at the Pulaski, Tennessee Frito-Lay facility, and since that day has made countless positive contributions to this company.
"He is a humble and collaborative leader who cares deeply about both the business and developing talent. John is also passionate about his family, and what is particularly impressive about his decision is that he is choosing what is right for him and his family.
"I have enjoyed a long friendship with John and will miss him. I'm confident John will enjoy great future success and we wish him all the best as he takes this unique opportunity to return to his native Tennessee."Follow @loullamae_es