It is combining its existing divisions in the UK and Ireland with nine Central European countries from the New Year. With headquarters in Prague, Molson Coors Europe will be run by Mark Hunter, chief executive of its Central European operations and a former marketer.
The top UK marketing role will be taken by director of customer marketing Andy Cray, who becomes director of brands.
McDonough joined Molson Coors in 2010 from Muller Dairies. He previously worked at Bacardi Martini and Mars Petcare in Germany.
During his time at the brewer, McDonough changed the positioning of its flagship brand Carling to highlight that the lager is 'brilliantly British'.
However, in a move that indicates the strategy may shift again, earlier this year McDonough called a review of the Carling brand's advertising.
VCCP, the incumbent on the account, is pitching against fellow roster agency Beattie McGuinness Bungay, Creature London and McCann London.