Fey, who starred in and created cult comedy ’30 Rock’, stars in one 60-second and two 30-second ads that depicts her balancing the pressures of family with a high-octane career.
The ads generated some buzz on Twitter last night, with people tweeting about how Fey holds the American Express EveryDay card upside down in the ad. American Express responded with a tweet in upside down, back-to-front text that when reorganised read: "Turning the credit card world upside down".
Fey is also appearing in print ads shot by photographer Annie Liebowitz.
The EveryDay card launches in the US on 2 April and is aimed at working mothers. It allows holders to collect rewards at shops they frequent, and if used for purchases 20 or more times during a billing period, users receive 20% extra in reward points.