Abbott Mead Vickers BBDO has 12 finalists, including its highly decorated Economist work.
DDB London is on course for a successful night with 20 entries shortlisted.
Much of the work is for its Volkswagen client, although its output for The Guardian also figures prominently.
Lowe will be looking to prove it has lost none of its creative potency with nine entries in line for an award, all of them for Nestle.
Mother has eight pieces of work up for final consideration, including executions for Coca-Cola, Orange and The Observer.
Saatchi & Saatchi will be looking for success with its powerful NSPCC work, while M&C is pinning most of its hopes on British Airways.
The awards ceremony will take place at London's Grosvenor House hotel on 13 October.
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