The agency will handle a range of digital activity, including creative and strategic work, as well as developing Nivea's UK website.
Until now, Nivea has not had a retained digital agency and has instead worked with shops on a project basis or used its advertising roster.
Agency Republic will work alongside DraftFCB, which became the lead global agency on the brand's $700 million global advertising account in November. The appointment ended TBWA's 25-year status as Beiersdorf's lead agency on Nivea.
Nivea's UK marketing activity includes a deal to sponsor This Morning, the ITV1 daytime programme. TBWA\London created idents for the sponsorship, which was announced last September.