The 90-second trailer, which breaks tonight and was produced by Red Bee Media, will appear before the films 'Cloverfield', 'Juno', 'John Rambo' and 'There Will Be Blood'.
The trailer is part of a BBC test with cinema sales house Carlton Screen Advertising to showcase BBC content. It will appear in 837 Odeon screens, 736 Cineworld screens and 142 Empire screens.
Naomi Gibney, head of marketing at BBC Vision, said: "This is a great opportunity for the BBC to reach new audiences with an exciting preview of the new series of Doctor Who."
Catherine Tate will reprise her role as Donna, the runaway bride, throughout the new series, alongside David Tennant as The Doctor.
The first episode of the fourth series will see Donna tracking down The Doctor during an alien emergency in modern-day London.
The fourth series of 'Doctor Who' is now in production and will hit BBC One in spring 2008.
The arrival of the new series comes as 'Doctor Who' spin-off 'Torchwood' has blasted its way straight to the top of BBC Two's ratings.
The new series, which has attracted criticism for risque storylines, pulled in 1m viewers -- more viewers than any other show on BBC Two last week. It follows Captain Jack Harkness, played by John Barrowman, and his team investigating alien and paranormal activity.
In its first week on the terrestrial channel, 4.2m people watched 'Torchwood' see off a threat from a rogue time-agent, played by former 'Buffy the Vampire Slayer' star James Masters. In the second episode the team solved a rift in time connecting the present to 1918 and the Great War.