The ads, which follow on from the agency's "It's a bit gorgeous TV work, continue Boddington's preference for humorous creative with a regional slant.
Featuring the endline, "Part of Manchester since 1778", the ads pay tribute to the contributions the Lancastrian city has made to the world.
One of the first ads commemorates Emily Pankhurst, who started the women's rights movement in Manchester. This execution features a female hand covering an empty pint of Boddingtons, preventing her husband from having his usual amount.
A later execution features a footballer's leg, with a pint of Boddingtons masquerading as a sock.
This is in reference to the first football league, which was set up in Manchester in 1888.
The advertisements will be launched in the Manchester press on 6 September.
BBH's creative directors, Nick Kidney and Kevin Stark, said: "The new campaign for Boddingtons is aimed at loyalist drinkers of cask-conditioned Boddingtons in Manchester.
"Boddingtons has been part of Manchester life for more than 200 years and we wanted to celebrate that.
"The campaign tells Mancunians things they probably didn't even know about their own city, that it has an impressive history of firsts."
The campaign was written by Kidney and art directed by Stark. It was illustrated by Ian Bilbey, with media buying through Starcom Motive.