Bartle Bogle Hegarty leads the UK field with six nominations, for Barnardo's "turn around", Robinsons' "put on a panto", Mentos "beatbox", Johnnie Walker's "the man who walked around the world" and two for Myspace "fan video".
Unit 9 notched up three, for its "king of Cannes" work for Stella Artois, "friend-o-meter" for Orange and "simply machines" for the Museum of Science and Technology.
Abbott Mead Vickers BBDO, Fallon, CHI & Partners, Anomaly, AKQA, Saint@RKCR/Y&R, DDB. OgilvyOne, Publicis, Work Club, Mother and Tequila London also had work shortlisted.
The UK has submitted 282 entries this year, second only to the US, which had a bumper year following a 40 per cent lift in entries, to total 636.
The number of UK entries was also up markedly from the 202 submitted in 2009’s recession-plagued decade-low.
Jeff Benjamin, the chief creative officer of Crispin Porter & Bogusky, said the Cyber Lions entries had been boosted by the difficult financial conditions throughout the past year.
He said: "This year, troubled economies conspired to push our creativity to new heights and into mediums and platforms that until now we could only dream about. More than ever, clients turned to digital for survival."
Benjamin added: "It meant we had to be more accountable. We had to be braver. But we also had to be more creative than ever before."
Last year, AKQA London was among the Cyber Lions Grand Prix winners for its work for Fiat. In total, 14 UK agencies were awarded a Cyber Lion last year, making it the second most successful country in the category.