The charity is talking to a number of undisclosed agencies about an anti-smoking brief. It is understood Lowe has been asked to repitch but RKCR/Y&R has pulled out.
The charity spent £1.5m on advertising in 2005, but it is understood its adspend could increase to as much as £7m this year.
BHF's main activity will be a follow-up to Lowe's "under my skin" television ad. The work showed blood clots travelling through smokers' veins towards their hearts to highlight the risk of smoking.
Work by BHF's previous agency, Euro RSCG, focused on smoking causing clogged arteries. It showed cigarettes dripping lumps of fat.
Colin Gurar, the head of marketing at BHF, is overseeing the pitch. He said: "The BHF always seeks to choose the right agency for each new advertising campaign. We do not retain agencies, but engage them on a project-by-project basis."
Media, handled by Manning Gottlieb OMD, is not thought to be affected by the pitch.
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