Bartle Bogle Hegarty has been shortlisted 38 times for its work for clients including Unilever and The Guardian.
Adam&Eve/DDB is the second most shortlisted agency with 27 nominations for work it created for brands such as Volkswagen and Harvey Nichols.
Abbott Mead Vickers BBDO has been shortlisted 19 times for work for the likes of Diageo and Mercedes, while CHI & Partners has 14 shortlisted entries for clients including News International.
Categories span across Direct, Film, Press, Interactive, Integrated, Outdoor and Radio. An award for a Campaign Big Agency of the Year will be made on the night of the awards in each category for the best-performing agency.
The awards will be held on 24 October in the Great Room at Grosvenor House, Park Lane, London. To view the full shortlist click here. The site also contains information about booking tickets for the awards night.