A spokesman for Channel 4 stressed the creation of agency-focused teams from September has not resulted in any job losses.
The sales team at Channel 4 was previously divided into product divisions, including trading, future media, strategic sales and sponsorship and airtime management.
Each agency team will incorporate specialists from each discipline and have a single agency lead that will provide a single point of contact for each agency and be knowledgeable about Channel 4 Sales' entire product portfolio.
It was revealed here in May that Channel 4 was working with BCG on a review of its sales team to look at how it can take advantage of changes in the ad sales and audio visual market.
BCG has previously worked as a consultant with ITV and BSkyB, resulting in significant departures at both broadcasters.
Following the restructure, Channel 4 will also introduce a portfolio and airtime management team. This will be a single team focused on balancing client relations and airtime optimisation, and dedicated portfolio teams that will work with their agency counterparts.
Andy Barnes, sales director at Channel 4, said: "I believe the new structure will result in a more integrated cross-product sales effort with better and clearer communication to our customers.
"It will allow us to sell a comprehensive product in a way that is efficient and flexible and it will ensure that Channel 4 Sales is best placed to achieve continued success in an increasingly converged and consolidated media environment."
Staff are being informed about the changes today following a process that has taken the broadcaster longer than expected. Chief executive David Abraham last month believed the restructure would be complete in early July.