Self replaces Jamie Craven who exited the shop in January, along with creative directors Andy McAnaney and Christian Sewell, to join Havas Worldwide London as its head of design.
He takes up the position with immediate effect and will report to the executive creative directors, Richard Denney and Dave Henderson.
He started his career at the branding agency N1 Creative and he has also worked at Rainey Kelly Campbell Roalfe/Y&R on campaigns for Virgin Atlantic and the Home Office.
Henderson said: "Ryan has an excellent pedigree and a fantastic eye. We're delighted he'll be casting his magic on our growing list of clients."
His appointment follows the recent hiring of Amber Casey and Lovisa Silburn as a creative team.