The campaign, created by DDB London and bought by Mediaedge:cia, uses the line "catch it, kill it, bin it", first created by Chick Smith Trott in 2007.
The campaign will warn the public about swine flu and advise them to cover their mouths when they sneeze and throw away used tissues.
The DoH is also distributing leaflets on the swine flu virus and preventative measures to all households in the UK from next Tuesday.
DDB London and MEC were appointed to the pandemic flu account last year.
The Government has been preparing for a possible influenza pandemic for a number of years, in line with the WHO's global influenza preparedness plan.
The pandemic alert reaches stage four when WHO deems there is sustained human-to-human transmission.
Swine influenza is a highly contagious acute respiratory disease of pigs, which is passed to humans.
As of 28 April, seven countries had officially reported cases of human infection: the US (64), Mexico (26, including seven deaths), Canada (six), New Zealand (three), and the UK, Israel and Spain (two each).