On Christmas Day, Heart DJ Jason Donovan will share the microphone with Alvin, a character from the film, as part of the promotion.
Alvin will host two hours of the show with Jason, "sharing Christmas stories and their favourite Christmas songs."
Additional activity will include Heart London's breakfast hosts, Jamie Theakston and Emma Bunton, running a daily competition to win a luxury island family holiday. There will also be trails and live reads, accompanied by information online.
Mike Gordon, Global Radio's managing director for commercial, said: "This is the first time we have teamed up with a commercial partner to have a character co-presenting a show and we're sure it will be entertaining to say the least.
"This promotion follows hot on the heels of the Capital promotion, which saw the Chipmunks interview some of the talent backstage at the Jingle Bell Ball and we're pleased to be working with 20th Century Fox to promote the film again."
Follow Mark Banham on Twitter @Banham72