The ad, which is part of a £5.5m integrated campaign created by CHI & Partners, sees the goldfish successfully navigate its way through a watery assault course, thanks to frequently being topped up by a bottle of Drench.
The campaign launches during 'Hollyoaks' at 6:45 pm on Thursday with a 10-second teaser spot, which directs consumers to the Drench website, www.staydrenched.co.uk, where a longer version of the story can be found.
The TV work is supported by a digital campaign, created by Elvis, that includes an augmented reality game, which consumers can access using a goldfish printed on the bottle's label.
By holding the goldfish up to a webcam, consumers will see a virtual fish tank appear on their computer screen, from which they can take part in a game where they must burst as many of Mr Memory's bubbles as they can.
If the competitor manages to record a score of 60% or more they are entered into a draw to win prizes such as free lunch at Boots for three months or a free magazine subscription.
The competition will be also be backed by a radio campaign, which launches on 1 March.
The new campaign follows a series of high-profile TV ads created by CHI & Partners for Drench in recent years.
In 2008 it launched a spot featuring Thunderbirds' Brains breakdancing to the song 'Rhythm is a Dancer', and followed this up last year with an ad that saw a cowboy riding a rodeo-pheasant.
Most recently, the brand rolled out an integrated campaign that featured four hamsters performing in a band called 'The Clever Hamsters'.