The charity is looking for an agency to help it explore its digital potential in the corporate sector, encouraging businesses of all sizes to get involved in partnerships.
The winning agency will be briefed to build a corporate web portal and create a variety of targeted online marketing campaigns.
Agencies are being contacted directly by the charity, which plans to hold a pitch later this month.
The appointment will be the first time that the Guide Dogs for the Blind Association has worked with an agency on its corporate business. It currently uses the Cheltenham-based DM agency TDA on its fundraising account. That relationship is unaffected.
TDA has worked with the charity since 2006, when it picked up the business after a pitch against WWAV Rapp Collins Bristol.
It has produced a number of DM, DRTV and digital campaigns for the organisation, as well as launching its "sponsor a puppy" scheme.