The male and female models were chosen in Harvey Nichols' "the best chest in Manchester" talent competition. They will feature on 48-sheet and six-sheet posters and press executions.
In one of two ads, a woman in a dress is shown with her breasts resting between the letters "Man" and "er", to make the word "Manchester".
In the second execution, the chest of a toned man in a stylish open-necked shirt completes the word.
Patrick McClelland and C Morgan, who art directed and wrote the campaign, said: "The client grabbed the opportunity with both hands, giving the campaign a local feel by using models living near the new store."
A radio campaign, running in the Greater Manchester region, will aim to demonstrate how the local population will be affected by having easy access to a store such as Harvey Nichols.
Media planning and buying was by Rocket Media.
Earlier this month, Harvey Nichols unveiled a campaign to promote its annual summer sale, featuring must-have designer items being torn apart by frenzied bargain hunters.