Kicking off on October 13, the print campaign features the former Sports Illustrated swimsuit model stretched atop the V-Rod Muscle, and will run in lifestyle magazines GQ, Esquire, Complex, Road & Track and Trader.
Ads will make use of new SnapTell technology, which provides access to exclusive content upon photographing the ad with a mobile phone camera.
The campaign was pre-launched on October 6 on Harley-Davidson's official YouTube channel, with a "making of" video showing a behind the scenes look at the Marisa Miller photo shoot.
Mark-Hans Richer, senior vice-president and chief marketing officer for Harley-Davidson, said: "The V-Road Muscle stands out in a crowd of copies and generic motorcycle profiles. It stretches the very definition of what it means to be a Harley-Davidson motorcycle."
Miller said: "To represent such an iconic American brand is incredible. I have grown up watching my dad and uncle ride Harleys. It's amazing to circle back at this point in my career, and work with a brand I have so much respect for."