Greene brings experience in both traditional and digital media formats, with previous stints at Time Inc, Content Solutions, and Columbia University.
She will report to Maxus' chief strategy officer, Mark Egan, who said: "By putting content at the heart of our planning, we aim to break through the clutter and engage audiences.
"In this way, Lori will help us unite customer touch points and integrate our clients' messaging. Along with data, content is a key area for engineering truly powerful communications strategies."
Earlier in her career, Greene held content-oriented staff and consulting roles with Reader's Digest Association Interactive, A&E TV Network, Court TV Online and the Food Network.