The agency won the business after a pitch against VCCP and M&C Saatchi in a process handled by the intermediary Oystercatchers.
Drinkaware, which aims to change people's drinking habits by highlighting the dangers of alcohol misuse, called a pitch for its integrated account in December. It previously worked with agencies including Abbott Mead Vickers BBDO, Enable Interactive and 23red on a project basis.
OgilvyOne will now be responsible for creating a series of onand offline campaigns that move the charity from general awareness communications to a more direct behavioural change approach.
Each campaign will target a specific category of society, such as 18- to 24-year-olds, adults over 30 or parents of young children.
The work will aim to build awareness of unit equivalents and alcohol guidelines, as well as challenge the social acceptance and desirability of drunken behaviour.
OgilvyOne will initially work on the account for three years, with its first work due to break later this year.
Chris Sorek, the chief executive of Drinkaware, said: "Our challenge is to present messages about alcohol misuse in a way that resonates with the target audience. A creative, evidence-based approach will be key."