The holding company behind DDB and OMD reported worldwide revenue of $12.5bn in 2010, up from $11.7bn in 2009.
UK revenue came in at £1.1bn, up 4.3% year on year and up 5.6% on an organic basis.
The group stepped up the pace in the fourth quarter with a 7.4% jump in profits to $246.5m after a 9.8% increase in revenue to $3.6bn.
Annual operating expenses rose 7% to $11bn.
Annual US domestic revenue climbed 8.2% to $6.7bn and international revenue rose by a slower 5.7% to $5.9bn.
Omnicom is the second of the top six global advertising and marketing groups to report its 2010 results.
WPP, which overtook Omnicom as the world's largest group by revenue in 2009, is due to report its 2010 results at the beginning of March.