The agency was handed the account following a four-way competitive pitch.
Ben Booth, the UK senior brand manager at Pernod Ricard, said: "Kameleon delivered the best pitch to win our business on Chivas in the UK. They were well versed in our brand and understood our issues and challenges."
A new campaign is due later in the year, with a four-strong Kameleon team working on the account, led by the agency co-founder, Richard Armstrong.
Armstrong said Kameleon was looking forward to "creating some great work and great results".
The appointment is not thought to affect Chivas Regal’s other agency relationships, which include Evolution Bureau handling the brand’s global social media and Havas Worldwide working on the global ad account.