The Leo Burnett-owned agency won the account after a competitive pitch.
Holler will now be responsible for working across Peroni's digital creative strategy, social media activity and web build.
It is understood that its first task is to handle the development of a mobile app for the beer brand.
Holler won the UK business from LBi, which was appointed to the account just over a year ago. However, LBi will continue to work on Peroni's global digital business.
The appointment of Holler strengthens Peroni's relationship with the Leo Burnett Group. Earlier this year, Peroni appointed the Leo Burnett-owned Arc to handle its direct marketing business.
The Bank currently handles Peroni's global advertising. The agency was behind last year's "primavera/estate" campaign. Its relationship is unaffected by the Holler appointment.
SABMiller and Holler were unavailable for comment.