The two men began their careers in advertising in 1996 at Bartle Bogle Hegarty, where they spent four years producing campaigns including Levi's "twins" spot, Lynx's original dreamdate spot featuring Jennifer Aniston, as well as work for One2One.
They moved to RKCR/Y&R in 2000 where they worked on Land Rover, Virgin Atlantic and Virgin Money, including the "Where are they now?" campaign for the financial services brand featuring Rainbow's Geoffrey and Dollar's David Van Day.
Al Young, the executive creative director at St Luke's, said: "We have important new-business wins to bed in and Brian and Jason are the right people for that job."
The hiring follows St Luke's recent appointment to the £3 million advertising account for Mothercare.