The television campaign for 'Super Mario 3D Land' features Cattrall in her bedroom reaching across to her bedside table and opening her Nintendo 3DS to indulge in some "me time".
She says her and Mario's shared loved of dressing up has kept things "interesting" over the years.
The creative highlights how Super Mario can provide the perfect escape for women and is designed to promote how important it is to make time for play whatever their age.
Vanisha Kavia, junior product manager at Nintendo UK, said: "The new campaign is all about women having fun.
"Kim Cattrall is an inspiration for women of all ages. She's attractive, successful, intelligent and knows how to have fun."
The TV campaign launches today (11 June) and runs for two weeks across the major analogue and digital TV stations. Karmarama created the ad, which was directed by Aneil Karia.
'Super Mario 3D Land' is the first-ever 3D Mario adventure game and features the Tanooki suit, which is based on the Japanese racoon dog.
Follow Matthew Chapman at @mattchapmanUK