The duo make their debut on Thursday in a 40-second commercial to reinforce the message from the satellite broadcaster that the Sky Plus video recorder can do seemingly incompatible things.
Hasselhoff, the world's most-watched TV star according to the Guinness Book of Records, and Reid, who played Frank Butcher in the BBC soap, join other unlikely combinations such as Alice Cooper and Ronnie Barker.
Unlike previous executions, however, the latest spot produced by HHCL/Red Cell, features the same commercial with eight different endings.
In the films, Hasselhoff is seen studying the finer points of animal husbandry as he tends his baby yucca plant. He asks Reid if it's possible to milk a pig. Reid admits he doesn't know and suggests they pick out their favourite Sky programmes so they can watch them whenever they want.
The commercial was produced by the HHCL creative team of Billy Faithful and Ross Neil and directed by Alan Coulter through Hungry Man. Universal McCann is handling media planning and buying.
Steve Henry, HHCL's creative director, said: "The new ads prove that the odd-couple formula has longevity and mass-market appeal."