The independent agency will predominantly be tasked with campaigns delivered through out-of-home, print and digital platforms. Publicis' Milan agency works with the brand and its London agency did some translation work for the brand last year.
St Luke’s has already been briefed on campaigns for spring 2014 and to support activity for the Heineken Cup, one of the most high-profile events in the rugby calendar, which kicks off in May. The account was awarded without a pitch.
David Lette, the premium brands director at Heineken, said: "St Luke’s have impressed us over the years with their outstanding work for Strongbow. They were the natural choice of partner to help us meet aggressive growth targets for Heineken in the UK."
The appointment does not affect the Heineken global creative account that has been run from the Wieden & Kennedy Amsterdam office since 2011.
Neil Henderson, the chief executive at St Luke’s, said: "It is a privilege to be working on one of most iconic brands ever. Our challenge is to create work that lives up to the standard set by some of the world’s greatest agencies."
Publicis Groupe-owned Starcom MediaVest Group handles the media planning and buying for the Heineken account.