SMG picked won The Media Network of the Year on the back of three Silvers, nine Bronzes and 14 shortlists in this year's Media Lions awards.
Winning campaigns have come from clients including Bank of America, Esurance, Heineken and Samsung, among others.
Laura Desmond, global chief executive of Starcom MediaVest Group, said: "I couldn’t be more proud of the work SMG is producing for its clients around the globe.
"Winning Media Network of the Year after our previous wins is truly incredible and proves that we’re at the top of our game. The work we’re producing for our clients is inspired by creativity and informed by converged data, a combination that is clearly resonating with the industry."