Following the building sale of the company’s Blue Fin headquarters in central London last year, staff will be relocated among four offices and asked to adapt to "more modern and flexible" working approaches.
A Time Inc spokeswoman confirmed that a redundancy consultation had begun but could not comment on numbers or what departments would be affected.
She said: "The market is tough and we are committed to ensuring that the business is in the best possible shape for the long term. Unfortunately this does include possible redundancies."
Some staff will be relocated to a newly refurbished office at 161 Marsh Wall, south of the Canary Wharf estate, while others will be spread between three other buildings: 5 Churchill Place in Canary Wharf, Pinehurst II in Farnborough, and the Blue Fin building.
The Blue Fin will remain the company’s registered head office and home to its central advertising team.
Sam Finlay will retain responsibility for digital ad revenues under his remit as chief revenue officer, while Andrea Davies, the group strategy and managing director, will take responsibility for further advancing Time Inc UK’s investment and acquisition pipeline.
Meanwhile, as part of an effort to achieve greater digital growth to long-term declines in print revenues, Time Inc is consolidating its digital operations under Neil Robinson, the digital director.
Robinson will oversee strategy, brand, product and audience development, as well as assuming responsibility for the majority of Time Inc’s brand websites.
Recent efforts to diversify income beyond print advertising include Marie Claire's move into ecommerce and retail by launching Fabled, a beauty brand. Also in July, the company acquired digital agency Collective UK to bolster its digital growth.
Marcus Rich, the chief executive of Time Inc UK, said: "It’s key to our being a modern media company and will provide the right environment to maximise our creativity.
"It also meets the needs of our people – in a recent survey, almost 70% expressed a wish to be able to work in a more flexible way. All of our key office spaces have been tailored specifically for us based on what our teams said they needed, be that hot desking, video and TV production facilities or a soundstage for bands to perform on.
"We already have premium content and data-driven intelligence, delivered at a scale which sets us apart. Now we are adding a renewed focus on digital growth, exciting new businesses such as events and ecommerce, and a modern way of working, we are in great shape for the future."