Mother, which has the account for TravelSupermarket’s parent Moneysupermarket.com, created the "holiday vs holiday" campaign that ran between 2013 and the end of 2014.
Mother will continue to work with the MoneySupermarket.com brand.
Initially, The Corner will work on a TV and digital campaign due to begin in the summer. Creative will include branding, marcomms, positioning, digital assets and above the line advertising.
Darren Bentley, the marketing director at TravelSupermarket, said: "The Corner showed comprehensive knowledge of the opportunities and challenges our business faces in 2015 and beyond."
Media for all the Moneysupermarket.com brands is by MediaCom.
Neil Simpson, a founding partner, The Corner said: "The travel sector has been revolutionised by comparison sites in recent years as customers become more independent at researching and booking their holidays online.
"This win is the perfect way for The Corner to kick off 2015."
Earlier this month The Corner-created TV ads for The Senet Group, which promotes responsible gambling, launched featuring Ram Jam's Black Betty.