Crispin scooped the Titanium Grand Prix for its "Twelpforce" campaign for Best Buy, which gave customers real-time expert technical help from a Best Buy staff member via Twitter, while Wieden & Kennedy Portland continued its impressive Cannes performance thanks to its "Livestrong" campaign for the Nike Livestrong Foundation.
The campaign helped to raise awareness of cancer by spraying messages of hope onto the Tour De France circuit during the race, using a special "Chalkbot" machine.
Overall, 16 Lions were handed out in the category, with Abbott Mead Vickers BBDO the only UK agency to emerge victorious.
AMV BBDO won Gold for its "Choose a different ending" work for The Metropolitan Police, which has already won Gold this week in Direct.
Three other Gold Lions were awarded, for campaigns including "Replay", created for Gatorade by TBWA\Chiat\Day Los Angeles. The work had already scooped two Grand Prix this week, in the Promo & Activation and PR categories.
The US was easily the most decorated country on the list, with ten of the 16 awards going to a US shop. The other countries to feature were Australia, Sweden, Brazil and New Zealand.