The agency's initial brief will be to promote the store upgrades and product innovations that Homebase has been working on for the past year.
It is thought that the agency's first work will appear in the pre-Christmas season.
The marketing procurement company RD Squared handled the review, which began in February this year. The incumbent on the account was Abbott Mead Vickers BBDO. The agency was asked to repitch for the business but pulled out early in the process for cost reasons.
Miles Calcraft Briginshaw Duffy and McCann Erickson were both involved at the shortlist stage but the former was removed in May, while the latter followed in June.
Paul Lawson, the group managing director of Leo Burnett & Arc, said: "Homebase as a business has been doing a lot of exciting work with its shop upgrades and we'll be expected to communicate that to the consumer at large."