The news of their departure coincides with the return of the Virgin presenter Steve Penk, who is coming back to the Manchester station to host an afternoon show.
Gus Mackenzie, the head of Key 103, said: "Key 103 is renowned for finding and developing the best talent on radio and once again Radio One has come knocking at our door. It's flattering that our skill in developing talent is recognised again and we wish the boys well."
The pair, who will Radio 1's weekend line-up from the summer, said: "We have had a great time working in Manchester but the chance to reach a national audience is just something we could not ignore. Radio 1 looks like a really exciting place to be at the moment -- it's going to be great to be a part of it."
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