The decision was taken after the centre failed to live up to initial expectations set when it opened in November 2011. There is currently no set date for closure.
A spokesperson from Bluewater said: "We continually review every aspect of Bluewater to ensure it delivers the very best offer and experience for our guests. Whilst welcoming more than two million people in three years, Glow did not meet these high expectations.
"Detailed discussions are underway with a number of leading brands and exciting concepts to create an offer within the space that adds significantly to Bluewater’s unique day-out experience."
The spokesperson added that the centre was still committed to hosting events and experiences.
Glow, which features an upper and lower hall as well as a gallery space, has previously hosted Build It Live, the Baby & Toddler show and a number of concerts and corporate events.
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