Bray Leino has restructured its Bristol agency in order to focus on direct response marketing, prompting the departure of Alistair Bryan and Jon Elsom.
Bryan, the chief executive at the Bristol office, is leaving after four years. He had previously worked at Iris.
Elsom, the executive creative director, joined in 2012 from DLKW Lowe.
During their tenure, Bray Leino won accounts including Legal & General and briefs from the Crown Commercial Service.
A spokesman said: "Bray Leino is undertaking a restructure that will see our Bristol agency focus on direct response with a strong data and digital base.
"As part of this initiative, Elsom and Bryan have amicably decided to step down from their roles with the agency. We wish them all the best."