The 30-second spot, released today, tells the story of a couple’s weekend in London and includes a nude bath scene.
It is the first commercial film by McQueen, who directed the multi-Oscar winning 12 Years A Slave in 2013. McQueen was nominated for Best Director, while the movie itself won Best Picture.
The ad stars actor Josh Whitehouse and model Amber Anderson, while the soundtrack, called I Won’t Complain, was written by British singer-songwriter Benjamin Clementine.
Burberry creates its advertising in-house, led by Christopher Bailey, the chief executive and chief creative. Bailey created the "Mr Burberry" campaign in collaboration with Francis Kurkdjian, a renowned French perfumer.
The global campaign launches today and will feature on online and social media channels, with further print and outdoor ads. Vizeum handles media planning and buying for Burberry.
Burberry has also set up a Discover channel on Snapchat, which will include style tips and the director's cut of the ad. The channel will only be live for 24 hours in the app, with content accessible afterwards by scanning a code on bottles of Mr Burberry with a smartphone.
Bailey said: "Mr. Burberry is our most significant men’s fragrance to date, inspired by the iconic Burberry trench coat and by London, a city of great contrasts and contradictions. It is traditional yet irreverent, elegant without being pristine.
"It perfectly encapsulates a mood and an attitude that today’s Burberry man will recognise as his own."