Blackhurst, who has been with ESI Media for 14 years, will continue to write regular columns and conduct weekly interviews for the newspapers and London Live TV.
His departure comes amid an ongoing redundancy programme, with the publisher looking to cut at least a dozen editorial roles.
Blackhurst was city editor of the Evening Standard for nine years before becoming editor of The Independent for two years.
He was then promoted to group content director. In September last year he took on the multi-media business role."
He said: "I’ve been thinking about extending my range of interests for some time. I made up my mind over Christmas.
"I’d like to see what other journalistic opportunities in print, digital and broadcast, directorships, advisory and consultancy roles are out there.
"I’ve been with this organisation 14 years, longer if you include my first spell with the Independent which began in 1992. It’s time to broaden my horizons."
Steve Auckland, ESI Media's chief executive, said: "We are delighted that Chris will continue to be a high-profile writer with our titles as we know how highly regarded he is by our readers and throughout the business world."