The truck has been decorated with fairy lights, a woodland snow scene, a festive fireplace and a Christmas tree.
Guests will be able to listen to Christmas music during their stay, watch their favourite festive film, open stockings filled with presents and tuck into a Coca-Cola or Coca-Cola Zero Sugar.
People will also be treated to a Christmas dinner, a festive breakfast and tickets to the Coca-Cola London Eye.
To be in with a chance of winning the experience, people will need to explain why they are the ultimate Christmas fan through the Laterooms.com listing by 8 December. The experience takes place at a "secret location" in London on 15 December.
Aedamar Howlett, marketing director for Coca-Cola Great Britain, said: "Coca-Cola is synonymous with the Christmas season and it’s no secret that our much-loved Christmas truck holds a special place in the heart of our fans.
"Christmas is all about sharing magical experiences with friends and loved ones – and so we can’t wait to invite one lucky pair of fans for the ultimate Christmas sleepover. After all, what could be more magical during the festive season than spending a night in the Coca-Cola Christmas truck?"