Powers joins the MDC Partners-owned agency from TBWA Worldwide, where she took global strategic responsibility for major Omnicom clients including GSK, Mars and Nivea.
She is a 10-year veteran of TBWA and has held several new business and strategy roles during her time at the network.
Andrew Keller, Crispin Porter + Bogusky chief executive, said: "We've found a restless kindred spirit in Suzanne with unmatched talent and experience in global planning and activation,
"It's time to change the current global agency model."
She will not be immediately replaced at TBWA Worldwide and members of her team will take up her responsibilities.
Powers added: "In this role, I'm lucky enough to get to work with an extremely talented group of people to take one of the most iconic agency brands and help that brand travel in a way that will unleash creativity and ideas across borders,"
Last month, Crispin Porter won the brief for Kraft chocolate brand Milka. It took the business in a pitch against incumbent Ogilvy & Mather and two undisclosed agencies.
Crispin Porter + Bogusky Europe is headquartered in Gottenburg, Sweden, but also has a newly opened London office, that will now act as the central hub for the Milka account.
The agency is known for opening offices in quirky locations including Boulder, Colorado in the US, and is also understood to have expansion plans in the Asia Pacific region and Latin America.