Three 30-second ads are running from today (11 January), ahead of the show's arrival in February on Sky 1.
They were filmed on location in Majorca and produced by Sky's in-house creative team.
Surreal scenes from the ads include cast members standing fully clothed in a swimming pool while being water-sprayed by Tiny Blair – a character from the series who wears a Tony Blair mask.
The ads will run on Sky 1, as well as UKTV channels Dave and Watch.
The ads are being complemented by a print and outdoor campaign, created by Brothers and Sisters, which will run from early February.
'Mad Dogs' stars Max Beesley and John Simm, and sells itself as a "darkly comic, twisted tale of friendship, put to the ultimate test".