The series, Blood Matters, consists of four short animated films that will run for four nights from 13 September in the 7.55pm post-Channel 4 News slot.
The series uses animated stories relevant to each of the target audiences.
For example, one tells the story of a girl with sickle-cell anaemia, an affliction that affects Afro-Caribbeans, while another tackles the issue that the Chinese consider blood to be something that should only be shared with family.
Drum worked with Katie Speight, Channel 4's commissioning editor, and the Documentary Film Makers Group. The films were produced by Andy Glynne, whose credits include Channel 4's mental-health series Animated Minds.
Mark Eaves, the head of TV at Drum, said: "This is funded TV that is of genuine value. It is innovative filmmaking with an innovative broadcaster, delivering a vital message."
This commission marks the second time that the National Blood Service has used Drum to create AFP - in December last year, it created a series of half-hour programmes called Lifeblood, in conjunction with Chrysalis TV and Enteraction TV, which ran on five.