The campaign by Euro RSCG London will launch on YouTube on 1 February, before airing on UK channels ITV and Channel 4 at the end of the month.
The activity will be supported by a Facebook game called "How in-sync are you?".
The campaign shows two turntables playing 'Let's Get it On' by Marvin Gaye at two different speeds, which slowly become in-sync with each other the play the track coherently.
The ad is intended to emulate the properties of the new Durex product, which is described by RB as "slowing him down and speeding her up", designed to create a mutual climax for both partners.
The game launches in the lead-up to Valentines Day, allowing consumers to be "in-sync" with their virtual gaming partner.
It will feature well-known tracks that consumers will need to speed up or slow down in order to hear them correctly.
Couples will need to stay in-sync for 10 seconds to prove their "virtual connection", which will be determined by a cross-fader mechanism to let couples get to the next level.
The creative team on the ad is Fabio Abram and Braulio Kuwubara, with creative directors Mick Mahoney and Brendon Wilkins.
Directors Si and Ad for Academy Films worked with producer Katie Dell and planner Yelena Gaufman.
The campaign is the first from EuroRSCG since it won the account in November 2010, following RB's acquisition of SSL, which owned the Durex and Scholl brands, in July 2010.
Follow Loulla-Mae Eleftheriou-Smith on Twitter @LoullaMae_ES