The move follows an international review process that began last year and had already seen ZenithOptimedia land the $45m US Gucci account.
ZenithOptimedia and its sister Publicis agency Digitas will now handle media planning and buying in the UK, France and markets in Asia excluding Japan for Gucci brands including Yves Saint Laurent, Bottega Veneta, Alexander McQueen and Stella McCartney.
The £2.5m UK Gucci account was previously held by MPG Media Contacts.
MPG’s loss of the UK account follows its capture of the $185m US LVMH media planning and buying account last summer.
Mindshare continues to handle Gucci's media across the rest of Europe while Hakuhodo retains the business in Japan.