The Rodale portfolio includes Men’s Health, Women’s Health, Prevention, Rodale’s Organic Life, Runner’s World and Bicycling.
Terms of the deal have not been disclosed but The Wall Street Journal is reporting a figure in the region of $225m.
The transaction is expected to complete in early 2018 following US government approval.
Hearst Magazines president David Carey said: "Maria Rodale has grown her family’s business into a peerless authority that reaches an enormous audience. Hearst and Rodale are already publishing partners around the world, including the UK, the Netherlands and Japan, and we’ve seen first-hand how the content resonates.
"We are pleased to add them and all of Rodale’s brands to our vibrant and varied global portfolio, providing readers with dependable information and offering marketers unbeatable scale and a trustworthy environment in the increasingly important health and wellness space."
Rodale chief executive Maria Rodale added: "We have a long-standing respect for Hearst’s commitment to connecting consumers with imaginative, engaging content across an ever-diversifying choice of platforms, technologies and experiences around the world."
Allen & Company acted as financial advisor in the sale and Wachtell, Lipton, Rosen & Katz is legal advisor.