The ad, which launches in December, marks the end of the telecoms company's six-year relationship with Mother, after the account was handed to Fallon in August as part of a consolidation.
The latest work, which encourages cinemagoers to switch off their mobile phones, sees Hopper pitching to the Orange Film Board while on a bus.
Mother has produced 20 celebrity-fronted Gold Spots since it won the account in 2002, securing the agency three gold Lions at Cannes, three golds at BTAA, a yellow Pencil at D&AD and a gold at this year's Campaign Big Awards.
United Kingdom
Hopper to front Mother's final Orange Gold Spot
LONDON - Dennis Hopper, the Hollywood actor and director, will take centre stage in Mother's last ever Gold Spot cinema ad for Orange.