The move adds to the site's 'social news' idea it introduced with Facebook Connect last year.
The Twitter Edition of the site offers breaking updates manually tailored to each section on the Huffington Post. The front page shows headlines, followed by a list of the top Breaking News Twitter accounts and up-to-the-minute tweets from each HuffPo channel.
The launch is part of HuffPo's drive to double revenues over the next year, although initially advertising is taking a back seat as the site encourages readers to use the new page.
HuffPo chairman Ken Lerer told PaidContent that the idea was to produce an entirely separate edition with the same kind of content as the main site, but created specially for Twitter users.
He said: "We think it's reasonable to assume that there will be more and more Twitter users; we think it's here to stay. As more users get accustomed to it, this will be a way that users will increasingly seek their news from our site."
Lerer added: "I can see people coming to the main site and going to the Twitter editions. Eventually, I can see people just going to the Twitter edition instead of the main Huffington Post sites and verticals. Ultimately, it will end up being as significant an addition to The Huffington Post as we've made to date."