The new assignment follows IPC's earlier use of the agency to take on the launch work for its new weekly title, Look.
Evelyn Webster, IPC Connect's managing director, said: "We wanted an agency that could add a new dimension to the brand's cut-through."
With a mixture of sex, murder, human interest stories, brainteasers and competitions, Pick Me Up has been hailed by IPC as a great success since its launch in 2005.
The work will make its debut at the end of the month.Nick Hurrell, one of the founding partners, cited June Smith-Sheppard's editorship as a key reason for Pick Me Up's success. He said: "It set the pace in the real-life market two years ago, and continues to do so."