The campaign, created by Lowe London, launches on Tuesday and will showcase the new collection of Spring Homeware.
Set on a theatre stage, the features four performances inspired by John Lewis products. They include a yellow parasol, cushions, a chaise longue and a variety of chandeliers. Each has a different musical style to complement the product.
The ad concludes with all four performers taking a bow and the endline "John Lewis. Set the stage for Spring".
The campaign features one 40-second spot and four 10-second spots. It will run for four weeks with its first slot during the Champions League on ITV1.
Gill Barr, the marketing director of John Lewis said: "We were keen to show how just one product can transform both a person's outlook and home. The ad aims to give our customers inspiration and to help them see their home in a new light."