The campaign features the strapline 'Feel Fabulous' and unveils the department store's Spring/Summer 2011 collection. It will premiere during Coronation Street's ad break on ITV1 tonight (14 February).
The ad, created by JWT and directed by Joanne Bailey, stars designers Jasper Conran, Ben de Lisi, Julien Macdonald, and Aliza Reger behind the scenes at a catwalk show.
Each designer sends their model down the runway and into an everyday scenario.
The national consumer print campaign will launch tomorrow.
Debenhams TV will also include extra material such as interviews with each designer, top picks and social media activity as well as footage that explains how the designers create their collections.
Michael Sharp, Debenhams deputy chief executive officer, said: "The 'Feel Fabulous' campaign really captures and celebrates the designers at Debenhams concept that we are so very proud of."
A second ad featuring designers Betty Jackson, Jeff Banks and John Rocha will air in the summer.